+ Product Information
Composition
Diosmin 1000 mg.
Therapeutic Effects
Flaben 1000 helps improve symptoms of chronic venous insufficiency of the lower limbs such as leg heaviness, leg pain and fatigue, numbness, nocturnal cramps, and edema.
It also supports the treatment of hemorrhoidal disease by relieving pain, reducing inflammation and swelling, and limiting bleeding during acute hemorrhoidal episodes.
Indications
Flaben 1000 is indicated for the treatment of venous and lymphatic circulation disorders, including chronic venous insufficiency of the lower limbs.
It is also used for the treatment of symptoms associated with acute and chronic hemorrhoidal disease.
Pharmacodynamics
Diosmin acts directly on the venous wall, increasing venous tone and reducing excessive venous distensibility.
It inhibits leukocyte activation and adhesion to the vascular endothelium, thereby reducing inflammatory processes in the vessel wall.
Diosmin also reduces the release of inflammatory mediators such as prostaglandins and thromboxanes, contributing to the reduction of pain and edema in venous disorders.
Pharmacokinetics
After oral administration, Diosmin is absorbed through the gastrointestinal tract and metabolized into diosmetin, its active form.
Peak plasma concentrations are reached within a few hours.
The active substance is mainly distributed in the venous system and related tissues.
Diosmin is primarily excreted in the feces, with a small portion eliminated via urine.
Its relatively long half-life allows once-daily dosing.
Dosage and Administration
The usual dose of Flaben 1000 is 1 tablet daily, taken during or after meals.
In acute hemorrhoidal attacks, higher doses may be used during the initial days as directed by healthcare professionals, followed by a maintenance dose.
Swallow the tablet whole with water; do not chew or crush.
Contraindications
Flaben 1000 is contraindicated in patients with hypersensitivity to Diosmin or any of the excipients.
Use is not recommended in individuals with a history of allergy to flavonoids.
Adverse Effects
The product is generally well tolerated.
Rare cases may include mild gastrointestinal disorders such as abdominal pain, diarrhea, or nausea.
Other possible effects include headache, dizziness, or allergic skin reactions such as rash and pruritus.
If serious adverse reactions occur, discontinue use and consult a healthcare professional.
Warnings and Precautions
Use with caution in pregnant and breastfeeding women, especially during the first trimester.
This product does not replace specific treatments for hemorrhoidal disease such as dietary modification, increased fiber intake, and appropriate physical activity.
Drug Interactions
No significant drug interactions have been reported with Diosmin.
However, patients should inform healthcare professionals about all medications and supplements being taken.
Storage
Store in a dry, cool place, protected from direct light.
Storage temperature: not exceeding 30°C.
Keep out of reach of children.
